The Evolving Landscape of Advanced Prostate Cancer Treatment: A Guidelines and Case-Based Discussion (2021)
Presented by the AUA in partnership with the Society of Urologic Oncology (SUO).
SUO strongly encourages that fellows participate in at least one SUO-sponsored educational course as available during their fellowship in addition to attending the Annual/Winter Meeting and the AUA/Spring Meeting. This educational course satisfies this recommendation.
Complimentary CME Course!
Thursday, September 9, 2021 | 8:30 AM - 5:00 p.m. PDT
Join Course Directors, Michael S. Cookson, MD, MMHC and David F. Jarrard, MD, in person or virtually on Thursday, September 9, 2021 for an educational initiative in advanced prostate cancer.
As a direct result of the significant increase in multiple FDA-approved therapeutic agents for use in patients with advanced prostate cancer, clinicians are challenged with a multitude of treatment options and potential sequencing of these agents that, consequently, make clinical decision-making more complex. This activity will build upon the newly updated 2020 AUA Guidelines on Metastatic Hormone Sensitive Prostate Cancer (HSPC) and Castration-Resistant Prostate Cancer (CRPC). Topics will include the latest on Genetic Testing in Advanced Prostate Cancer and the Role of Immunotherapy and PARP Inhibitors.
Designed for residents, fellows and APPs as well as urologists and other health care providers who care for patients with prostate cancer, this interactive hybrid forum will focus on the application of knowledge with case studies and small group discussion via breakout rooms integrated throughout the day. A flipped classroom approach will be utilized. Register early to receive the Prework Library which will be available to all registered participants in August 2021. Participants will be expected to complete the Prework Library in advance of attending the live course - complete the prework on your own time, at your convenience. Then, come prepared on September 9 to actively engage with peers as you apply what you've learned.
Pre-registration is required for the in person and virtual offering as space is limited for both.
Needs assessment findings show strong support for continued development of courses and educational materials specifically targeted at residents and fellows that cover the medical management of advanced prostate cancer. This activity may also be of interest to urologists and other health care providers who care for patients with prostate cancer.
The Live Forum will cover the following topics*:
- Identification of High Risk Disease and Initial Management of Biochemical Recurrence
- Imaging of Advanced Prostate Cancer
- Manipulating the Androgen Axis: New Agents in mHSPC and CRPC
- M0 CRPC: Treatment Options and Goals of Therapy
- Radionuclide Therapy and Bone Health
- Role of Immunotherapy and PARP Inhibitors
*Visit the program tab for full details.
Support provided by independent educational grants from:
Bayer HealthCare Pharmaceuticals Inc.
- Advanced Practice Provider (Nurse Practitioners & Physician Assistants)
At the conclusion of this activity, participants will be able to:
PRACTICE GAP #1 (DISEASE STATE)
- Describe the natural course of advanced prostate cancer from non-metastatic (M0) to metastatic hormone-sensitive disease (mHSPC), with progression to the development of castration-resistant disease (CRPC).
- Describe the treatment options and outcomes for patients with biochemical recurrence after failed local therapy.
- Identify available imaging and indications for use including next generation PET imaging in the assessment of men with biochemical recurrence after failed local therapy.
- Describe the treatment options and outcomes for newly diagnosed mHSPC.
- Explain the implications of CRPC on the management of both M0 and M1.
- Discuss the molecular mechanisms and characterization of CRPC.
- Discuss the incorporation of genetic testing (both germline and somatic testing) into the management of men with high risk, metastatic prostate cancer and CRPC.
PRACTICE GAP #2 (GUIDELINES)
- Discuss specific recommendations within the AUA Clinical Practice Guidelines.
- Define M0 CRPC and the treatment options.
- Discuss clinically meaningful endpoints in clinical trials of patients with M0 CRPC.
- Describe gaps in the knowledge for treatment and sequencing of agents in the management of CRPC.
- Discuss challenges in incorporating AUA Guidelines and management of advanced mHSPC and CRPC into community practice.
PRACTICE GAP #3 (ANDROGEN AXIS)
- Identify approved androgen biosynthesis and receptor blockers for treatment of CRPC.
- Appraise the clinical use and efficacy of approved androgen-axis therapeutics for CRPC.
- Anticipate, manage and treat adverse events from therapeutic interventions directed at the androgen-axis used in the treatment of CRPC.
- Discuss new uses for androgen axis agents in M0 CRPC.
PRACTICE GAP #4 (CHEMOTHERAPY, IMMUNOTHERAPY, PARP INHIBITORS AND CO-MORBIDITY)
- Identify approved chemotherapeutics, immunotherapy and PARP Inhibitors for mCRPC.
- Describe indications and contraindications for chemotherapy, immunotherapy and PARP Inhibitors in patients with mCRPC.
- Identify co-morbid states and recognize their impact on treatment options for mCRPC.
- Identify germline and somatic mutations and implications for treatment in mCRPC including indications for PAPR Inhibitors and pembrolizumab.
- Discuss treatment sequencing in the advanced, metastatic and CRPC disease state.
PRACTICE GAP #5 (BONE HEALTH AND RADIONUCLIDE THERAPY)
- Integrate advances in bone health management into patient-specific care plans.
- Identify patients and prescribe radionuclide therapy in appropriate patients with symptomatic mCRPC.
- Discuss known adverse events associated with androgen biosynthesis inhibitors and radionuclide therapy.
PRACTICE GAP #6 (PAIN MANAGEMENT AND PALLIATIVE CARE)
- Assess and manage pain in patients with symptomatic mHSPC and mCRPC.
- Discuss the role of chemotherapy, performance status and pain management in patients with mCRPC.
- Review the role of palliative care and supportive services in the management of late stage CRPC.
8:30 – 8:35 a.m. Welcome
Michael S. Cookson, MD, MMHC & David F. Jarrard, MD
8:35 – 8:45 a.m. Pre-Test
Michael S. Cookson, MD, MMHC & David F. Jarrard, MD
8:45 – 9:05 a.m. Identification of High-Risk Disease and Initial Management of Biochemical Recurrence
9:05 – 9:25 a.m. Imaging of Advanced Prostate Cancer and Impact on Cancer Management
9:25 – 9:40 a.m. M0 CRPC: Treatment Options and Goals of Therapy
9:40 – 10:40 a.m. Case-based Roundtable Discussions: Recurrent and nonmetastatic CRPC
- Case #1 –BCR & Novel PET Imaging– Dr. Boorjian
- Case #2 – M0 CRPC – Dr. Cookson
Roundtable Discussants: All Faculty
10:40 – 10:55 a.m. Break
10:55 – 11:15 a.m. Manipulating the Androgen Axis: New Agents in mHSPC and CRPC
11:15 – 11:35 a.m. Genetic Testing in Advanced Prostate Cancer
11:35 a.m. – 12:30 p.m. mHSPC: Maximal Androgen Targeted vs Chemohormonal Therapy for mHSPC and Management of Oligometastatic Disease
Dr. Jarrard & Dr. Lang
12:30 – 1:45 p.m. Non-CME Lunch Symposium - TBD
1:45 – 2:05 p.m. Bone Health and Radionuclide Therapy
2:05 – 2:25 p.m. Role of Immunotherapy and PARP Inhibitors
2:25 – 3:20 p.m. Case-based Roundtable Discussions: Chemotherapy-naïve metastatic CRPC
- Case #3 - Early M1 CRPC (Docetaxel vs. AR vs. Sipleucel-T) – Dr. Stratton
- Case #4 - Advanced M1 CRPC (Docetaxel and Ra-223) – TBD
Roundtable Discussants: All Faculty
3:20 – 3:35 p.m. Break
3:35 – 4:00 p.m. Role of Chemotherapy, Treatment Sequencing in mCRPC and Future Directions
4:00 – 5:00 p.m. Case-based Roundtable Discussions: Post-Chemotherapy metastatic CRPC
- Case #5 - Role of Genetic Testing in Advanced M1 CRPC (Immunotherapy or PARP Inhibitors) – Dr. Gomella
- Case #6 - M1 CRPC Post-docetaxel, Neuroendocrine Cancer and End-of-Life Care – Dr. Lang
Roundtable Discussants: All Faculty
Education Council Disclosures
COI Review Work Group Disclosures
AUA Office of Education Staff has nothing to disclose.
Faculty disclosures will be posted here prior to the start of the course.
All relevant financial relationships have been mitigated.
The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The American Urological Association designates this live activity for a maximum of 6.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.
EVIDENCE BASED CONTENT:
It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.
AUA DISCLOSURE POLICY:
All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider any relevant financial relationships with any commercial interest. The AUA must determine if the individual’s relationships may influence the educational content and resolve any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.
MITIGATION OF IDENTIFIED CONFLICT OF INTEREST:
All disclosures will be reviewed by the AUA Conflict of Interest (COI) Review Work Group for identification of conflicts of interest. The AUA COI Review Work Group, working with the program directors and/or editors, will document the mechanism(s) for management and mitigation of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to mitigate conflict of interest:
- Peer review for valid, evidence-based content of all materials associated with an educational activity by the course/program director, editor, and/or AUA COI Review Work Group.
- Limit content to evidence with no recommendations
- Introduction of a debate format with an unbiased moderator (point-counterpoint)
- Inclusion of moderated panel discussion
- Publication of a parallel or rebuttal article for an article that is felt to be biased
- Limit equipment representatives to providing logistics and operation support only in procedural demonstrations
- Divestiture of the relationship by faculty
OFF-LABEL OR UNAPPROVED USE OF DRUGS OR DEVICES:
The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.
AUA PARTICIPANT INFORMATION & POLICIES
Disclaimer: The opinions and recommendations expressed by faculty, authors and other experts whose input is included in this program are their own and do not necessarily represent the viewpoint of the AUA.
Consent to Use of Photographic Images: Attendance at or participation in AUA meetings and other activities constitutes an agreement by the registrant to AUA's use and distribution (both now and in the future) of the attendee's image or voice in photographs and electronic reproductions of such meetings and activities.
Audio, Video and Photographic Equipment: The use of audio, video and other photographic recording equipment by attendees is prohibited inside AUA meeting rooms.
Reproduction Permission: Reproduction of written materials developed for this AUA course is prohibited without the written permission from individual authors and the American Urological Association.
Special Assistance/Dietary Needs: The AUA complies with the Americans with Disabilities Act §12112(a). If any participant is in need of special assistance or has any dietary restrictions, please see the registration desk.
Registration is complimentary. Registrants must select either the in person or live virtual (streaming) method of participation at the time of registration.
Attendee Information & Policies
AUA Anti-Harassment Policy
AUA Commitment: AUA is committed to providing a safe and productive meeting environment that fosters open dialogue and the exchange of scientific ideas and is free of harassment and discrimination. All meeting participants are expected to behave professionally and treat others with respect, follow venue rules, and alert AUA staff or security of any dangerous situations or anyone in distress.
Reporting Harassment: It is the policy of the AUA that all meeting participants will enjoy an environment free from discrimination, harassment or retaliation. Harassing or offensive behavior by meeting participants will not be tolerated. If an individual experiences or witnesses harassment, he or she should contact Janet Skorepa, AUA EVP, at jskorepa@AUAnet.org or Diane Bieri, AUA General Counsel, at dbieri@AUAnet.org or use a venue phone and ask for security if he or she feels unsafe. All complaints will be treated seriously and responded to promptly.
The AUA reserves the right to take any action deemed necessary and appropriate, including refusing or revoking the registration of any individual, without refund, as long as such refusal is consistent with applicable law and AUA policy.
Disclaimer: The opinions and recommendations expressed by faculty, authors and other experts whose input is included in this program are their own and do not necessarily represent the viewpoint of the American Urological Association (AUA).
Consent to Use of Photographic Images: Registration and attendance at or participation in AUA meetings and other activities constitutes an agreement by the registrant to AUA's use and distribution (both now and in the future) of the registrant or attendee's image or voice in photographs, videotapes, electronic reproductions, and audiotapes of such events and activities.
Audio, Video, Photographic Equipment: The use of audio, video and other photographic recording equipment by attendees is prohibited inside AUA meeting rooms.
Reproduction Permission: Reproduction of written materials developed for this AUA course is prohibited without the written permission from individual authors and the AUA.
Special Assistance/Dietary Needs: The AUA complies with the Americans with Disabilities Act §12112(a). If any participant is in need of special assistance or has any dietary restrictions, a written request should be submitted at least one month in advance. For additional assistance with your request please call 1-800-908-9414.